Cancer Therapy: Preclinical Galeterone Prevents Androgen Receptor Binding to Chromatin and Enhances Degradation of Mutant Androgen Receptor
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چکیده
Purpose: Galeterone inhibits the enzyme CYP17A1 and is currently in phase II clinical trials for castration-resistant prostate cancer (CRPC). Galeterone is also a direct androgen receptor (AR) antagonist andmay enhance ARdegradation. This studywas undertaken to determine themolecular basis for AR effects and their therapeutic potential. Experimental Design: Effects of galeterone on AR expression and activities were examined in prostate
منابع مشابه
Galeterone prevents androgen receptor binding to chromatin and enhances degradation of mutant androgen receptor.
PURPOSE Galeterone inhibits the enzyme CYP17A1 and is currently in phase II clinical trials for castration-resistant prostate cancer (CRPC). Galeterone is also a direct androgen receptor (AR) antagonist and may enhance AR degradation. This study was undertaken to determine the molecular basis for AR effects and their therapeutic potential. EXPERIMENTAL DESIGN Effects of galeterone on AR expre...
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تاریخ انتشار 2014